Thermodynamic properties of hydroxypropyl-?-cyclodextrin/guest interaction: a survey of recent studies

Abstract For many years, cyclodextrins (CDs) have been the object of attention for their capability improving stability, solubility and bioavailability numerous molecules interest, including drugs nutraceuticals. They low toxicity this reason employed different routes administration, oral, ocular, nasal parenteral. Among them, hydroxypropyl-?-cyclodextrin (HP-?-CD) is least toxic. Several physicochemical methodologies studying cyclodextrin/guest interaction, but isothermal titration calorimetry (ITC) only one capable simultaneously providing binding constant, ? H °, S G ° stoichiometry. Here, we present state art ITC studies applied to HP-?-CD/guest complexes, discussing selected publications last five highlighting thermodynamic factors that are decisive optimal encapsulation.